Jobs
>
Dundee

    Postdoctoral Research Assistant: Chemical Biology - Dundee, United Kingdom - University of Dundee

    University of Dundee
    University of Dundee Dundee, United Kingdom

    1 week ago

    Default job background
    Full time, Fixed-Term/Contract
    Description

    Modification of proteins with ubiquitin-like proteins (Ubls) is a critical cellular process linked to pathogen resistance, cancer, and selective organelle degradation. Central to their conjugation to substrates are E3 ligase enzymes (E3s), yet for many Ubls the E3s are poorly understood or remain completely unknown. The Virdee lab has pioneered the development of activity-based probes (ABPs) for the related ubiquitin system, which has led to several field-changing discoveries (Pao et al., Nat Chem Bio 2016; Pao et al., Nature 2018; Mathur et al., Cell Chem Biol. 2020; Mabbitt et al. Nat Chem Biol This project will build upon this expertise and expand its approach to Ubl systems. Ubl E3 ABPs will be constructed using the lab's modular chemical protein synthesis methods. These powerful tools will then be deployed in combination with proteomics to discover entirely novel E3 ligases. The transformative understanding of these understudied posttranslational modifications will enrich our understanding of the cellular function of these modifiers and could enable the development of new therapeutic targets.

    Enthusiastic candidates should ideally have recently carried out a PhD in biochemistry or a chemistry related area. The position will be a fantastic opportunity for candidates to broaden their skillset by working in a multidisciplinary lab using state-of-the-art technologies. Coupled with this exciting area of biological focus, the project will provide an excellent opportunity for career development with mentoring support to reach career aspirations. The successful applicants will join an international team in an exciting and interactive environment, equipped to the very highest standards, and with generous consumable support.

    Yourprioritieswillinclude:

    • Carry out chemical protein synthesis of protein-based probe molecules for Ubl E3s
    • Perform assays using purified protein and cell extracts
    • Preparation of data for manuscript preparation
    • Liaise with other lab members and collaborators
    • Maintenance of meticulous lab records

    Who we're looking for:

    Enthusiastic candidates should ideally have recently carried out a PhD working in structural biology or biochemistry.

    • Enthusiasm for technology development working at the chemistry-biology interface
    • Experience with chemical biology techniques
    • Biochemical experience

    This contract is for a fixed term period of 3 years

    MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU):

    The MRC PPU is one of the world's most renowned centres for research on protein phosphorylation and ubiquitylation ). Many world-leading researchers in the field of signal transduction have trained within the MRC PPU. The major aims of the MRC PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation and ubiquitylation, to generate reagents and improve technologies. A key remit of the MRC PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research.

    School of Life Sciences (SLS):

    The MRC PPU is based within the School of Life Sciences at the University of Dundee, a world-class academic institution with a reputation for the excellence of its research, its high-quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

    Division of Signal Transduction Unit (DSTT):

    The Division of Signal Transduction Therapy (DSTT) was established in 1998. This division operates as a unique collaboration between scientists in the MRC PPU and signalling researchers at the University of Dundee's School of Life Sciences and three leading pharmaceutical companies (Boehringer lngelheim, GlaxoSmithKline, Merck Serano). The DSTT is widely regarded as a model for how academia should interact with industry. The DSTT operates as a simple bridging mechanism to enable our Pis working on ubiquitylation and phosphorylation to effectively interact with three major pharmaceutical companies to help accelerate the early stages of drug discovery. The DSTT model enables industrial researchers working in any of the worldwide outlets of three pharmaceutical companies to effectively work with the ~200 Dundee-based researchers that participate in the collaboration to understand the fundamentals of the molecular causes of disease that result from disruptions in protein phosphorylation and ubiquitylation networks.

    We are one of the UK's leading universities - internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and­ coming, friendly, compact and affordable city with a rich heritage in design and technology. Just a short walk from the V&A Museum of Design Dundee, we're close to both the train and bus stations. We also have campuses at Ninewells Hospital and in Kirkcaldy which are easily accessible via local transport links.

    For further information about this position please contact Satpal Virdee To find out more about the MRC Protein phosphorylation and ubiquitylation unit please visit

    Commitment to DORA

    The School of Life Sciences has been fully committed to the principals of the San Francisco Declaration on Research Assessment (DORA) since 2013. In assessing applicants, we consider the scientific quality of their published research papers, but do not take into account where the papers were published and do not consider journal-based metrics, such as Journal Impact Factors.

    The diversity of our staff and students helps to make the University of Dundee one of the top universities in the UK. Family friendly policies, staff support networks for BME and LGBT staff, membership of Athena Swan and Stonewall, achievement of the Race Equality Charter, as well a full range of disability services, create an enjoyable and inclusive place to work.

  • Springer Nature

    Koodac Team Chemical Biologist

    3 days ago

    Springer Nature Dundee City, United Kingdom

    **KOODAC Team Chemical Biologist**: · - Employer- Havas People- Location- Dundee City (GB)- Salary- Grade 7 (Spinal Point £36,024- £44,263)- Closing date- 14 Jun 2024- Discipline · Biomedicine, Chemistry, Clinical, Health Science · Job Type · Faculty Member, PhD Position, Profess ...

  • Springer Nature

    Koodac Team Structural Biologist

    3 days ago

    Springer Nature Dundee City, United Kingdom

    **KOODAC Team Structural Biologist**: · - Employer- Havas People- Location- Dundee City (GB)- Salary- Grade 7 (Spinal Point £36,024- £44,263)- Closing date- 14 Jun 2024- Discipline · Biomedicine, Chemistry, Clinical, Health Science · Job Type · Faculty Member, PhD Position, Profe ...

  • University of Dundee

    Postdoctoral Research Assistant

    3 days ago

    University of Dundee Dundee, United Kingdom

    **Postdoctoral Research Assistant - MRC PPU**: · - Employer- University of Dundee- Location- Dundee, Dundee City (GB)- Salary- £36,024 - £44,263 pa- Closing date- 7 Jun 2024- Discipline · Chemistry · Job Type · Postdoctoral, Research Assistant · Employment - Hours · Full time · D ...

  • W.L. Gore & Associates

    Chemical Regulatory Affairs Specialist

    2 days ago

    W.L. Gore & Associates Dundee, United Kingdom

    **About the Role**: We are looking for a Chemical Regulatory Affairs Specialist (f/m/d) to join the team, providing expertise on chemicals, regulations, material composition and material chain of custody. This key role supports the businesses to develop, make and sell products gl ...

  • Springer Nature

    Postdoctoral Researcher

    1 day ago

    Springer Nature Dundee, United Kingdom

    **Postdoctoral Researcher**: · - Employer- UNIVERSITY OF DUNDEE- Location- Dundee, Dundee City (GB)- Salary- Grade 7 £36,024- £42,978- Closing date- 18 May 2024- Discipline · Life Science · Job Type · Researcher · Employment - Hours · Full time · Duration · Fixed term · Qualifica ...

  • University of Dundee

    KOODAC Team Senior Lead Scientist

    1 week ago

    University of Dundee Dundee, United Kingdom Full time

    We are recruiting for an exceptional individual with expertise in Chemical Structural Biology and/or Medicinal Chemistry applied to Drug Discovery to join the group of Professor Alessio Ciulli as a Senior Lead Scientist within the expanding Centre for Targeted Protein Degradation ...

  • University of Dundee

    KOODAC Team Structural Biologist

    1 week ago

    University of Dundee Dundee, United Kingdom Full time

    We are recruiting for an exceptional Structural Biologist / Biophysicist with experience in studying structures of protein- ligand and protein-protein complexes to join the group of Professor Alessio Ciulli as a Postdoctoral Research Assistant within the expanding Centre for Targ ...

  • University of Dundee

    KOODAC Team Chemical Biologist

    1 week ago

    University of Dundee Dundee, United Kingdom Full time

    We are recruiting for an exceptional Chemical Biologist / Biophysical Chemist with experience in compound screening and assay development to join the group of Professor Alessio Ciulli as a Postdoctoral Research Assistant within the expanding Centre for Targeted Protein Degradatio ...

  • UNIVERSITY OF DUNDEE

    Postdoctoral Researcher

    6 days ago

    UNIVERSITY OF DUNDEE Dundee, United Kingdom

    We are recruiting a highly motivated Postdoctoral Researcher to join the laboratory of Dr Kirby Swatek. The goal of the Swatek lab is to understand the immunoregulatory roles of a ubiquitin-like modifier called Interferon-Stimulated Gene 15 (ISG15). As its name suggests, ISG15 is ...

  • Havas People

    KOODAC Team Senior Lead Scientist

    1 week ago

    Havas People Dundee City, United Kingdom Full time

    Position 1 - Senior Lead Scientist: Chemical Structural Biology / Medicinal Chemistry (KOODAC team) Unit: Centre for Targeted Protein Degradation · Fixed-Term for 5 years · Grade 8 (Spinal Point £45,585- £54,395) · We are recruiting for an exceptional individual with expertise in ...

  • University of Dundee

    KOODAC Team Senior Lead Scientist

    3 days ago

    University of Dundee Dundee, United Kingdom Full time, Fixed-Term/Contract

    We are recruiting for an exceptional individual with expertise in Chemical Structural Biology and/or Medicinal Chemistry applied to Drug Discovery to join the group of Professor Alessio Ciulli as a Senior Lead Scientist within the expanding Centre for Targeted Protein Degradation ...

  • University of Dundee

    Postdoctoral Research Assistant

    3 days ago

    University of Dundee Dundee, United Kingdom Full time

    Chemical Biology - Discovery Probes for Ubiquitin-like E3 Ligases · Modification of proteins with ubiquitin-like proteins (Ubls) is a critical cellular process linked to pathogen resistance, cancer, and selective organelle degradation. Central to their conjugation to substrates a ...

  • University of Dundee

    Postdoctoral Research Assistant

    1 week ago

    University of Dundee Dundee, United Kingdom Full time

    The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high-quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over ...

  • UNIVERSITY OF DUNDEE

    Postdoctoral Research Assistant

    4 days ago

    UNIVERSITY OF DUNDEE Dundee City, United Kingdom Full time

    Enthusiastic candidates should ideally have recently carried out a PhD in biochemistry or a chemistry related area. The position will be a fantastic opportunity for candidates to broaden their skillset by working in a multidisciplinary lab using state-of-the-art technologies. Cou ...

  • Havas People

    KOODAC Team Structural Biologist

    1 week ago

    Havas People Dundee City, United Kingdom Full time

    Position 3 – Structural Biology / Biophysical Assay Development PDRA (KOODAC team) · Unit: Centre for Targeted Protein Degradation Fixed-Term for 5 years · Grade 7 (Spinal Point £36,024- £44,263) · We are recruiting for an exceptional Structural Biologist / Biophysicist with expe ...

  • W. L. Gore & Associates

    Chemical Regulatory Affairs Specialist

    1 week ago

    W. L. Gore & Associates Dundee, United Kingdom Full time

    About the Role: We are looking for a Chemical Regulatory Affairs Specialist (f/m/d) to join the team, providing expertise on chemicals, regulations, material composition and material chain of custody. This key role supports the businesses to develop, make and sell products global ...

  • Havas People

    KOODAC Team Medicinal Chemist

    1 day ago

    Havas People Dundee, United Kingdom

    Position 4 – Medicinal Chemistry / Organic Chemistry PDRA (KOODAC team) · Unit: Centre for Targeted Protein Degradation Fixed-Term for 5 years · Grade 7 (Spinal Point £36,024- £44,263) · We are recruiting for an exceptional Medicinal Chemist / Synthetic Organic Chemist with expe ...

  • Havas People

    KOODAC Team Chemical Biologist

    2 weeks ago

    Havas People Dundee City, United Kingdom Full time

    Position2–ChemicalBiology/ScreeningAssayDevelopmentPDRA(KOODACteam) · Unit:CentreforTargetedProteinDegradation Fixed-Termfor5years · Grade 7 (Spinal Point £36,024- £44,263) · We are recruiting for an exceptional Chemical Biologist / Biophysical Chemist with experience in compou ...

  • University of Dundee

    KOODAC Team Structural Biologist

    3 days ago

    University of Dundee Dundee, United Kingdom Full time, Fixed-Term/Contract

    We are recruiting for an exceptional Structural Biologist / Biophysicist with experience in studying structures of protein- ligand and protein-protein complexes to join the group of Professor Alessio Ciulli as a Postdoctoral Research Assistant within the expanding Centre for Targ ...

  • University of Dundee

    KOODAC Team Chemical Biologist

    3 days ago

    University of Dundee Dundee, United Kingdom Full time, Fixed-Term/Contract

    We are recruiting for an exceptional Chemical Biologist / Biophysical Chemist with experience in compound screening and assay development to join the group of Professor Alessio Ciulli as a Postdoctoral Research Assistant within the expanding Centre for Targeted Protein Degradatio ...