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    Analytical Scientist - United Kingdom - Astrea Bioseparations group

    Astrea Bioseparations group
    Astrea Bioseparations group United Kingdom

    1 week ago

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    Description

    Astrea Bioseparations Ltd is a global bioseparations company specializing in the research, development and manufacture of advanced bioseparation products including chromatography adsorbents and columns. A wholly owned subsidiary of Gamma Biosciences, Astrea Bioseparations has R&D laboratories in Cambridge, UK and manufacturing facilities on the Isle of Man, British Isles and Stoughton, Massachusetts, making the company one of the largest volume affinity adsorbent manufacturers in the world.

    Astrea Bioseparations is honored to support the biopharmaceutical industry with products and services that help bring lifesaving and improving medicines to market. Regardless of process scale, we are ready to build Purity by Design into each process to ensure quality and speed to market.

    The company is now entering an exciting period of growth as we work towards enabling our customers to bring advanced therapies to market using state-of-the-art-purification nanofiber-based technology.

    Reporting to the Director of Delivery R&D, you will join a high performance, high impact R&D team.

    This is an exciting time for Astrea with our growth into the Cell and Gene therapy space and the launch of our Fiber chromatography, AstreAdept.

    We are looking to hire an analytical scientist to work in R&D with in-depth knowledge of analysis of biomolecules, to contribute to our product and applications development.

    You will have an in-depth knowledge of analytical techniques and how to optimise and troubleshoot them.

    You will be skilled at analysing and presenting analytics data.

    You will help, train, and supervise other scientists in the lab.

    The role requires collaboration, experimental design skills, data analysis and project management.

    Principle Responsibilities:

    The key responsibilities of the role are;

    • Analytical method development and optimisation:
      1. Lead the design and optimization of analytical methods to characterize Biomolecules and VLPs (Virus Like Particles).
    • Data Analysis: Utilize your expertise to analyze complex analytical data, generate meaningful insights, and provide recommendations for process improvement and product development.
    • Instrumentation: Manage and maintain state-of-the-art analytical instrumentation and equipment, ensuring their proper function and calibration.
    • Documentation: Maintain comprehensive documentation of experimental procedures, results, and reports, adhering to regulatory and compliance standards.
    • Collaboration: Work closely with cross-functional teams, including research scientists, engineers, and regulatory affairs, to support research and development efforts.
    • Training: training and upskilling other scientists
    • Upholding health and safety requirements
    • Other related duties/responsibilities as required or assigned by the supervisor.

    In addition, you will be expected to

    • Keep up to date with developments in the field.
    • Serve as a consultant within the organisation sharing your expertise on Analytics, acting as a technical expert advising and sharing scientific technical expertise with top management, customers and product management on applications and research.

    Minimum Qualifications:

    • In-depth knowledge of various analytical techniques for biological molecules such as mAbs, proteins, nucleic acids, or viral vectors.
    • In depth knowledge of analytical HPLC including analytical SEC (Size Exclusion Chromatography), analytical ion exchange and reverse phase. With proven experience of running, setting up and troubleshooting these methods.
    • Extensive experience in Mass Spec
    • Proficiency in data analysis software and statistical tools.
    • Excellent problem-solving skills and attention to detail.
    • Proven track record of analysing biological molecules and interpreting the data produced.
    • Effective communication skills to collaborate with multidisciplinary teams and present findings to diverse stakeholders.
    • Ability to work on multiple projects at the same time.
    • Ability to set up and optimise analytical methods for use in an R&D setting.

    Preferred Qualifications:

    Other useful skills include:

    • Design of Experiment
    • Determination of AAV (Adeno Associated Virus) full-empty ratio.
    • Experience with SPR, DLS (Dynamic Light Scattering), IEF, Protein melting temperature determination, accelerated stability studies for proteins, capillary electrophoresis.
    • Hands on experience of analysis of DNA, Viruses and Virus like particles would be seen as an advantage.
    • Keen to learn and enthusiastic with an interest in furthering Bioproduction through the innovation of the next generation of chromatography tools.
    #J-18808-Ljbffr
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