Molecular Biologist - Didcot, United Kingdom - Medical Research Council

Medical Research Council Didcot, United Kingdom

3 weeks ago

Description

View Vacancy -- Molecular Biologist - MLC 2394

Open Date 15/04/2024, 00:00 /*generated inline style */ Close Date /*generated inline style */ 19/05/2024, 23:55 /*generated inline style */ Research Institute 1 MRC Mary Lyon Centre /*generated inline style */ Research Institute / Unit Information 1 The (MLC) is located in an expanding science and innovation campus in Oxfordshire and is an internationally renowned centre at the forefront of genetics research. As the hub of the new National Mouse Genetics Network, the specialist facilities and capabilities of the MLC support a number of research groups across the UK to accelerate our understanding of human diseases, such as cancer, developmental disorders and neurodegeneration. /*generated inline style */ UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

/*generated inline style */ Band 1 MRC - 4 /*generated inline style */ Location 1 Harwell Campus, Oxfordshire /*generated inline style */ Salary 1 £39,375–£43,962 per annum, dependent on skills and experience /*generated inline style */ Contract Type 1 Permanent /*generated inline style */ Job Type 1 Technical & Scientific Professionals /*generated inline style */ Full Time / Part Time 1 Full Time /*generated inline style */ Job Description 1

Overall Purpose:

The Mary Lyon Centre at the Medical Research Council Harwell (MLC) is recruiting a Molecular Biologist to work as part of a genome engineering team and on a collaborative technology development programme in Genome Editing and Engineering. The successful candidate will work within the Molecular and Cellular Biology (MCB) group and in close collaboration with the Genotyping core facility. Their activity will span genome editing and gene targeting of the mouse genome at scale and functional validation of engineered alleles.

The available post is based within established laboratories that have significant existing expertise in genome engineering in the generation and quality control of engineered mouse alleles. The successful candidate will work as part of a team and will be responsible for the design and validation of genome-engineered mouse models. They will advise genome editing service users. They will design genetically altered alleles, editing reagents and genotyping assays. They will work collaboratively with the MCB team and with the MLC groups responsible for mouse production, breeding and embryo manipulation. They will review the data for validation of new alleles. The post-holder will collaborate with other senior members in the group to analyse production data, refine lab processes and present findings in publications. They will work as part of a team and, once familiar with the service's work, participate in the team's programme of technology development.

An understanding of gene structure and expertise in standard molecular biology techniques (PCR, sequencing) are required. Previous experience in the analysis of Sanger sequencing data is desirable. Specialist training in genome engineering can be provided.

Main Duties/Key Responsibilities:

Design and validation of genome-edited mouse models

Liaison with Genome Editing and Engineering Service users

Coordination of molecular biology tasks in the MCB team and collaboration with other teams in the Mary Lyon Centre

Review of data and production processes as part of a team

Design of new engineered alleles

Dissemination of knowledge in genome engineering, taking part in writing publications and teaching at specialist workshops

Working Relationships:

Design and validate genome-engineered alleles for the generation of models, working as part of a team with the other Molecular and Cellular Biology (MCB) team members, including direct reports, and reporting to the Head of MCB

Work with scientists in the various research groups, to help design alleles for new mouse models

Interface with the senior team of the Mary Lyon Centre, including the Director and Heads of Departments, to deliver key programmes and services

Additional Information:

Some flexible working patterns and paid weekend work may be required at the discretion of the supervisor.

/*generated inline style */ Person Specification 1

Education/Qualifications/Training Required:

Essential:

PhD in Biological Sciences, or equivalent, involving the use of molecular biology

Understanding of gene structure/function

Previous Work Experience Required:

Essential:

Use or generation of genetically altered cell lines or animals

Extensive use of PCR-based techniques

Previous experience in genotyping

Desirable:

Experience of Sanger sequencing or digital PCR

Evidence of quality- and customer-focused work

Knowledge and Experience:

Essential:

Experience of several of the following Molecular and Cellular Biology techniques: gene targeting, genome editing, PCR, Sanger sequencing analysis, ddPCR, in vitro transcription

Computer literacy is essential for the recording and communication of results

Desirable:

Working and adhering to standard operating procedures and experience of process analysis and refinement

Experience in service provision

Personal skills/Behaviours/Qualities:

Essential:

Organised and hard-working, with a strong eye for detail

Able to work well as part of a team and develop leadership skills

Desirable:

Able to communicate clearly and concisely with a variety of scientists at all levels (from principal investigator to research assistants and animal technicians)

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