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Senior Protein Engineer
3 weeks ago
Umbilical Life Nottinghamshire, United Kingdom Full timeMy client is an innovative start-up who aims to introduce an exciting era of protein production. · The client is looking for a full-time, on-site experienced protein engineer who will play an integral role in the development and optimisation of downstream processes for the extra ...
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Research Associate in Recombinant Spider Silk
2 weeks ago
University of Sheffield Sheffield, United KingdomA Research Associate position is available to join a UKRI/EPSRC funded team to study the potential of recombinant spider silk proteins to be spun into high performance fibres by developing high throughput characterisation equipment. This is to be undertaken in the Natural Materia ...
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Research Associate in Biomanufacturing
3 weeks ago
University of Sheffield Sheffield, United KingdomAre you interested in working in a world top 100 University? We have an exciting opportunity in the Department of Chemical and Biological Engineering for someone with a passion for alternative proteins research looking to utilise his/her skills to make an impact on the food indus ...
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Biological Research Technologist
3 weeks ago
Protiomix Limited Sheffield, United Kingdom**Biological Research Technologist (PBRT Sheffield, U.K.** · Protiomix is a private-equity-backed company with a bold, carbon-negative vision for the future of animal feed and pet food, fully integrated into the UK Bioeconomy. We combine cutting-edge chemical and biological engin ...
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University of Sheffield Sheffield, United KingdomAre you Interested in working for a world top 100 university? We have an exciting opportunity in the Department of Chemical & Biological Engineering for someone with a passion for research looking to use their skills in cultivating microalgae to make an impact on sustainable manu ...
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Research Associate
2 days ago
University of Sheffield Sheffield, United KingdomAre you interested in working as part of a large collaborative team that will employ an innovative multidisciplinary strategy to dissect the molecular mechanisms of ribosome specialisation? · A postdoctoral Research Associate position is available in the research group of Dr Emma ...
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Research Associate in Biomanufacturing
7 hours ago
University of Sheffield Sheffield, United KingdomThis is an exciting opportunity for a highly motivated postdoctoral research associate interested in working at the academic-industrial interface to join our team. You will be leading a highly innovative project to develop molecular tools for laboratory evolution of bacteria and ...
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Production Lead
3 weeks ago
AGRECRUIT LIMITED Doncaster, United KingdomOpportunity to play a critical role in a Plant Proteins start-up business. · - Leadership position with equity options. · **KEY SKILLS / EXPERIENCE REQUIRED**: · - Demonstrable track record in Production and Process Management relating to Food and/or Protein based products. · - E ...
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Research Fellow in Plant Proteins Extrusion
1 week ago
University of Leeds Leeds, United Kingdom**Research Fellow in Plant Proteins Extrusion**: · **Are you an ambitious researcher looking for your next challenge? Do you have a strong background in food science/technology at PhD level? Do you have experience in protein functionality and processing? Do you want to further yo ...
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Lead Scientist
2 weeks ago
VRS Recruitment Macclesfield, United KingdomOur client is a specialist national organisation that brings together leading UK scientists and industry to accelerate innovative drug discovery projects. They provide unique scientific capabilities to support and drive the discovery of new medicines anddiagnostics. · They are se ...
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University of Leeds Leeds, United Kingdom**Research Fellow in Lectin Clustering and Signalling**: · **Are you an ambitious researcher looking for your next challenge? Do you have a background in protein functional studies? Are you interested in exploiting multidisciplinary approaches to address challenging biological qu ...
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University of Leeds Leeds, United Kingdom**Research Fellow in Sustainable Fermentation-based Proteins**: · **Are you an ambitious researcher looking for your next challenge? Do you have an established background in food biotechnology **and interests in designing novel alternative protein-based food products with optimiz ...
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Molecular Biologist
4 days ago
CroBio® macclesfield, United Kingdom £38,000Company Overview: · At CroBio, we're on a mission to revolutionise agriculture in the face of climate change. With the global food supply at risk due to declining agricultural productivity, unpredictable harvests, and reduced yields, our work has never been more vital. We innovat ...
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Molecular Biologist
5 days ago
CroBio® Macclesfield, United KingdomJob Description · Company Overview: · At CroBio, we're on a mission to revolutionise agriculture in the face of climate change. With the global food supply at risk due to declining agricultural productivity, unpredictable harvests, and reduced yields, our work has never been more ...
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Senior Scientist
5 days ago
CroBio® Macclesfield, United KingdomJob Description · Company Overview: · At CroBio, we're on a mission to revolutionise agriculture in the face of climate change. With the global food supply at risk due to declining agricultural productivity, unpredictable harvests, and reduced yields, our work has never been more ...
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Senior Scientist
4 days ago
CroBio® macclesfield, United KingdomCompany Overview: · At CroBio, we're on a mission to revolutionise agriculture in the face of climate change. With the global food supply at risk due to declining agricultural productivity, unpredictable harvests, and reduced yields, our work has never been more vital. We innovat ...
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Molecular Biologist
5 days ago
CroBio® Macclesfield, United KingdomCompany Overview: · All potential applicants are encouraged to scroll through and read the complete job description before applying. · At CroBio, we're on a mission to revolutionise agriculture in the face of climate change. With the global food supply at risk due to declining ag ...
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Senior Scientist
3 days ago
CroBio® Macclesfield, United KingdomCompany Overview:nAt CroBio, we're on a mission to revolutionise agriculture in the face of climate change. With the global food supply at risk due to declining agricultural productivity, unpredictable harvests, and reduced yields, our work has never been more vital. We innovate ...
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Molecular Biologist
3 days ago
CroBio® Macclesfield, United KingdomCompany Overview:nAt CroBio, we're on a mission to revolutionise agriculture in the face of climate change. With the global food supply at risk due to declining agricultural productivity, unpredictable harvests, and reduced yields, our work has never been more vital. We innovate ...
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Senior Scientist
4 days ago
CroBio® Macclesfield, United KingdomCompany Overview: · Please double check you have the right level of experience and qualifications by reading the full overview of this opportunity below. · At CroBio, we're on a mission to revolutionise agriculture in the face of climate change. With the global food supply at ris ...
Protein Engineer - Sheffield, United Kingdom - Hlx Life Sciences
Description
Role SummaryIn this role you will be a core part of the Protein Engineering team, working collaboratively with other protein engineers and biochemists to develop soluble high affinity bispecific TCR molecules suitable for later stage clinical development.
Key DeliverablesTest, screen and produce soluble TCR-based therapeutics for clinical development using cutting-edge molecular biology techniques, protein engineering methodologies, and structural biology approaches
Will include:
# Develop and undertake established and novel strategies to affinity mature candidate soluble TCRs
# Design and construction of affinity maturation TCR libraries
# Screening of affinity maturation libraries outputs for affinity and cross reactivity
# DNA recombinant subcloning
# Sequence analyses of the library outputs
Collaboratively with the Biology and CMC teams to guide optimization and development of soluble TCRs. Design and conduct experimental work to align with Company priorities and meet scientific timelines, report results succinctly and effectively. Work to your department, project team and the company leadership team. Collaboratively with the other teams to guide optimization and development of soluble TCRs. Design and conduct experimental work to align with Company priorities and meet scientific timelines, report results succinctly and effectively. Scientific findings and summary conclusions to your department, project team and the company leadership team.
Experience & Qualifications Required
Provide oversight of specific elements within a project or projects and supervise other scientists. A PhD in a relevant biological subject alongside some postdoctoral experience and/or experience in the biotech/pharma industry. (Desired but not essential) Experience line managing/supervising other scientists. (Desired but not essential) Experience working in a matrix environment. Direct hands-on laboratory experience in developing high affinity antibodies or soluble TCR molecules using molecular evolution approach (phage display, yeast display etc.
Strong proven expertise in molecular biology and protein engineering techniques, including rational design, phage display, library construction, affinity maturation approaches, site directed mutagenesis, cloning.
Experience in screening affinity maturation outputs and candidate molecules through techniques such as ELISA, DNA sequence analyses etc. (Desired but not essential) Experience in purifying and refolding proteins. (Desired but not essential) Experience in analyses of protein affinity and cross-reactivity using SPR/Biacore.Working proactively with the team to develop effective strategies prioritized to the needs of the Protein Engineering group; collaborating effectively with other functions.
Inclusive, collaborative, and thrives in a team environment with a flexible approach to working. Strong communication skills with the confidence and judgment to challenge appropriately. Demonstrable problem-solving ability, creative thinking and be pro-active in driving the project forwards;#J-18808-Ljbffr
