nata 2391 - London, United Kingdom - Medical Research Council

Description

View Vacancy -- NATA Postdoctoral Researcher – Biology MRC Nucleic Acid Therapy Accelerator

Open Date 11/04/2024, 12:00 /*generated inline style */ Close Date /*generated inline style */ 12/05/2024, 23:55 /*generated inline style */ Research Institute 1 NATA /*generated inline style */ Research Institute / Unit Information 1 The Medical Research Council (MRC), as part of UK Research and Innovation (UKRI), has invested a total of £30M over 5 years to establish the Nucleic Acid Therapy Accelerator (NATA) that will support state-of-the-art interdisciplinary research to solve critical issues in nucleic acid therapeutics. NATA has state of the art chemistry and biology laboratories and capabilities located on the Harwell Research and Innovation Campus, Oxfordshire alongside the MRC Harwell Mary Lyon Centre, National Mouse Genetics Facility. This internationally unique resource is focussed on bringing together key stakeholders in the field to tackle and solve significant problems facing oligonucleotide therapy design, manufacture and delivery to key organs. This investment will support capacity building in terms of equipment, upskilling and domain expertise that will be essential in developing critical mass to catalyse and de-risk the development of next generation nucleic acid therapeutics. /*generated inline style */ UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

/*generated inline style */ Band 1 MRC - 4 /*generated inline style */ Location 1 London /*generated inline style */ Salary 1 £39,375-£41,843 per annum (depending on experience, plus inner London weighting) /*generated inline style */ Contract Type 1 Fixed Term /*generated inline style */ Job Type 1 Science /*generated inline style */ Full Time / Part Time 1 Full Time /*generated inline style */ Contract Length 1 23 months /*generated inline style */ Job Description 1 We are seeking to appoint a highly motivated and enthusiastic postgraduate scientist to work on a collaborative project between NATA and University College London (UCL). The project aims to develop personalized antisense oligonucleotide (ASO) therapy for beta-propeller protein-associated neurodegeneration (BPAN), a rare early onset disorder affecting neuronal function. The researcher will work on the developing in vitro cell based models to evaluate the impact of oligonucleotide treatment on important cellular functions autophagy. The successful candidate is expected to have a strong work ethic, knowledge of in vitro modelling with hiPSC-derived neurones and to be experienced in cell and molecular biology. The NATA employee will be seconded to work full-time in the laboratories of Professor Manju Kurian and will interact with the research team led by Dr Haiyan Zhou, all based at the UCL GOS Institute of Child Health, London. /*generated inline style */ Person Specification 1

Responsibilities

Undertake laboratory experiments as required by the project and analyse/report data (presentations, verbal and written report)

Develop monogenetic disease modelling for the evaluation of oligonucleotides

Identify, develop and apply different techniques as required to pursue the research objectives

Prepare standard protocols for novel methods

Ensure all work is carried out in accordance with the host institution's regulations

Update co-supervisors in a timely way on any results and prepare research updates regularly

Keep excellent scientific records

Contribute to the smooth running of the group, including the effective use and management of resources, training of others and taking responsibility for use of communal facilities

Enhance your research and generic skills through a tailored development programme

Present work internally and at national and international meetings

Maintain a good knowledge of the relevant literature and of the wider field and actively promote this to the group

Work effectively with collaborators

Supervise students, visitors and trainees as necessary on specific projects

The postholder will carry out any other duties as are within the scope, spirit and purpose of the job as requested by the co-supervisors.

Essential selection criteria

Hold a relevant in biology, pharmacology, toxicology or a related discipline

Peer-reviewed research publications commensurate with career stage

Background in working on monogenetic disease modelling, in particular, in vitro modelling with hiPSC-derived neurones

Experience in reprogramming patient-derived cells into hiPSCs

Experience in maintenance and differentiation of PSCs

Experience in elucidation of disease mechanisms with standard laboratory techniques (qRT-PCR, Western blotting, confocal microscopy etc)

High-level of creativity and independence in developing innovative analysis methods and solving complex problems

Experience and knowledge of data analysis and interpretation

Experience of managing biology projects and resources

Excellent oral and written communication skills

Ability to analyse data in the literature and place own work in the context of work in the field

Passionate about collaborative working and building relationships to reach common goals

High level organisational skills, with the ability to manage a broad range of jobs simultaneously and under pressure

Flexible and adaptable, able to manage changing priorities

Capable of critical thinking

Working and adhering to standard operating procedures and experience of process analysis and refinement

Organised, hard-working with a strong eye for detail and able to work as part of a team

Demonstrate ability to meet milestones

Desirable selection criteria

Interdisciplinary skills with an emphasis on chemistry/pharmacology, especially quantification methods and characterization of nucleic acid-protein interactions

Experience of the analysis of oligonucleotides: quantification, localization, stability

Fundamental knowledge in the regulation of gene expression, RNA splicing, and protein translation

Knowledge of nucleotide structure and modifications

Publications as first/co-author in peer reviewed journals

Presentation at national/international conferences

/*generated inline style */ The MRC is a great place to work and progress your career, be it in scientific research or the support MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.

We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations