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    Immunology Scientist - London, United Kingdom - Deep Science Ventures Limited

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    Description

    You will be joining a new company founded via a venture creation partnership between Deep Science Ventures and AbbVie, to be based in the London area.

    The technology we're building has been based on devising and de-risking a novel nucleic acid-based approach to restore immune tolerance via promoting the reprogramming of pathogenic tissue-resident memory cells to tolerogenic cells.

    The company is now seeking a scientist with expertise in immunology and T cell biology to help progress its novel approach.

    The company is continuing to expand its scientific leadership team and already has a strong and growing advisory board.

    With projections indicating the global market for anti-inflammatory drugs could reach £165 billion annually by 2030, the urgency for curative therapies has never been more pronounced.

    Despite advances in biologic treatments transforming the IMID treatment landscape over recent decades, these therapies often yield suboptimal results, benefiting only a subset of patients while fostering drug resistance or causing significant side effects.

    The complexity of IMIDs, rooted in an intricate interplay of genetics and environmental triggers, continues to elude complete understanding.

    This complexity underscores the limitations of current therapeutic strategies and the pressing need for innovative approaches that offer genuine cures and sustainable drug-free recovery.


    WHAT WE ARE BUILDING

    Through the development of novel nucleic acid vectors, we aim to unlock naturally occurring tolerance mechanisms to provide durable, disease-specific therapies.

    By combining DSV's venture creation prowess with AbbVie's therapeutic expertise, we are uniquely positioned to drive this project forward, mark a new chapter in the treatment of inflammatory diseases, and create lasting impact in the fight against these debilitating conditions.

    We are looking for a passionate and motivated scientist with strong immunological expertise and track-record in immunology, to drive forward the science of this early-stage biotech.

    Designing, refining and optimising the experimental work plan and scientific process;
    Orchestrating the development of cutting-edge oligonucleotide therapeutics for critical in vitro and ex vivo translational studies in order to assess efficacy, toxicology and PK/PD profiles of those drugs in the context of our technology;
    Planning in vivo biodistribution and efficacy studies;
    Ensuring that all techniques are updated with the latest advancements in the field;
    Ensuring data quality and integrity, to align with objectives and deadlines;
    Crafting compelling data packages and presentations for investor conversations.
    You have a PhD in immunology (or MRes + 5 years of relevant work experience).
    You are driven by unsolved challenges in medicine, especially immunology and autoimmunity, and have the ambition to work with a team to build new solutions resulting in curative therapies
    A deep biological understanding of immune cell biology, particularly immune cells present within inflammatory disease
    Flow cytometry (multi-colour experimental & panel design, cellular phenotyping and analysis)
    ELISA/MSD analysis of cytokines
    You are innovative, creative, and guided by first-principles thinking
    Track record of high quality publications in the field, or thought leadership in the field
    Bioinformatics and data analysis skills
    Salary benchmarked against similar stage companies, with an attractive share option plan for early hire
    Potential for performance linked equity awards

    We provide optimised, purpose-built, proprietary tools, resources and processes to help create high-impact ventures from scratch, using our venture creation methodology.

    We draw on opportunity area specific know-how provided by our network of Partners and Advisors;
    DSV provide continuous support after post spin-out, including fundraising, commercial partnerships, recruitment and team-building (amongst other things);
    Deep Science Ventures is creating a future in which both humans and the planet can thrive.

    We use our unique venture creation process to create, spin-out and invest into science companies, combining available scientific knowledge and founder-type scientists into high-impact ventures.

    Pharmaceuticals, Climate, Agriculture and Computation, tackling the challenges defining those areas by taking a first principles approach and partnering with leading institutions.

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