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    Doctoral Research in Natural - London, United Kingdom - Scholarshipscafe

    Scholarshipscafe
    Scholarshipscafe London, United Kingdom

    1 week ago

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    Description

    Doctoral Research in Natural & Mathematical Sciences, King's College London, United Kingdom Mechanosensing proteins detect mechanical forces within cells and convert them into biochemical signals.

    Understanding the dynamic behaviour of these proteins under force is key for advancing our understanding of this process called mechanotransduction.

    Recent advances in single-molecule magnetic tweezers instrumentation have opened up exciting possibilities for studying these proteins under physiologically relevant forces, providing unprecedented insights into their functional states as done in a recent study by Rafael Tapia-Rojo.

    The typical readout of such measurements is a stochastic trajectory that randomly oscillates around certain equilibrium points and quickly switches between them.

    In these trajectories, the signal is embedded in noise. We have recently developed machine-learning techniques to measure physical parameters from the stochastic motion of individual molecules.
    Requirements

    Applicants should have, or expect to have, an integrated Master's (e.g., MSci) with first-class honours or upper division second-class honours (2:1), or a BSc plus Master's (MSc) degree with Merit or Distinction in Physics, Biophysics, Applied Mathematics, or related subject.

    Equivalent international degrees are equally accepted. The funding is not restricted to specific nationalities.

    The successful applicant will demonstrate strong interest and motivation in the subject, and ability to think critically and creatively.

    Previous research experience in biophysics and or an interdisciplinary research environment is desirable.
    Application

    Interested candidates are invited to contact the main supervisor (Stefano Bo) with a transcript, CV, and motivation letter expressing interest in the project.

    Informal enquiries are encouraged.
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