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    Research Fellow - London, United Kingdom - UCL Eastman Dental Institute

    UCL Eastman Dental Institute
    UCL Eastman Dental Institute London, United Kingdom

    1 week ago

    Default job background
    Permanent
    Description

    About the role

    A position has become available for a post-doctoral research fellow to work in the Regulatory Genomics lab, headed by Professor Richard Jenner. The Regulatory Genomics laboratory uses genomics, bioinformatics, molecular and biochemical techniques to identify how transcription factors, chromatin modifiers and RNA binding proteins regulate cell differentiation and how defects in these processes cause cancer. The lab has particularly focused on the role of polycomb proteins ( Beltran et al., Nat Struct Mol Biol ; Hall Hickman & Jenner, Cell Rep ) and control of T cell differentiation ( Hertweck et al., Nucleic Acids Res ).

    We have recently determined how fusion of the polycomb protein SUZ12 to JAZF1 drives changes in gene expression and cell state in endometrial stromal sarcoma (Tavares et al., ).

    The research fellow will lead experiments seeking to determine how these changes in gene expression protect tumour cells from immune-mediated clearance and whether these expression changes can be inhibited. The research fellow will also determine whether other oncogenic fusion proteins operate in a similar way.

    This post is funded for 2 years in the first instance. The proposed end date will be June .

    About you

    The post holder should have a PhD (or be in the process of submitting a PhD) in molecular biology, immunology or a related subject. The post holder should have research experience in transcriptional or epigenetic regulation, particularly in cancer, or in immune cell function, especially in the tumour microenvironment.

    What we offer

    As well as the exciting opportunities this role presents we also offer some great benefits some of which are below:

  • 41 Days holiday (including 27 days annual leave 8 bank holiday and 6 closure days)
  • Defined benefit career average revalued earnings pension scheme (CARE)
  • Cycle to work scheme and season ticket loan
  • On-Site nursery
  • On-site gym
  • Enhanced maternity, paternity and adoption pay
  • Employee assistance programme: Staff Support Service
  • Discounted medical insurance
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