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    Project Researcher - Norwich, Norfolk, United Kingdom - The John Innes Centre

    The John Innes Centre
    The John Innes Centre Norwich, Norfolk, United Kingdom

    1 week ago

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    Full time
    Description

    Applications are invited for a Postdoctoral researcher to join the group of Prof Saskia Hogenhout (twitter: @The post holder will investigate interactions of phytoplasma effector proteins with host targets using yeast two-hybrid assays, mutagenesis, co-immunoprecipitation experiments, mass spectrometry, biophysical analyses, structure-function assays and (confocal) microscopy.

    They will apply bioinformatics and protein engineering approaches to study the functions of domains within proteins and modulate them.

    They will generate stable and transient transgenic plant lines and conduct a diverse range of assays with plant pathogens, insects and plants.

    The post holder will work within a team of individuals experienced in molecular plant-biotic interactions, biochemistry, protein structural biology, evolutionary genomics and bioinformatics.

    The appointee will work closely with the Group Leader, Research Assistant and other lab members of the Hogenhout group.

    They will also interact with other research groups and staff of the technical platforms of the Norwich Research Park and (inter)nationally.

    The successful candidate will assist in the training of others, including (under)graduate students, in a collaborative environment. contact will include Research Support staff, Postdocs, student communities and external collaborators.
    Percentage Identify, plan, carry out and modify experiments to meet the objectives of the project 65 Prepare results, reports and manuscripts for publication in leading scientific journals and other relevant media 5 Disseminate research findings through presentations to various audiences at internal, national and international meetings 5 Collaborate with colleagues within the Institute in the development of original and world-class research, including contributing to research proposals and grant applications 5 Liaise with industry and other external stakeholders 5 Ensure research and record keeping is carried out in accordance with good practice, Scientific Integrity and in compliance with local policies and any legal requirements 5 Contribute to the smooth running of the group, including the effective use of resources, supervision of visitors to the laboratory and assisting with training others, encouraging scientific excellence 5 As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees 5
    Requirement Importance BSc or equivalent in Molecular Biology Essential PhD (full award or expected within 6 months) or equivalent in Molecular Biology or a related discipline Essential
    Requirement Importance Knowledge of cellular biology Essential In depth knowledge of plant genetics Essential Knowledge of microbiology Essential In depth knowledge of molecular host-microbe interaction processes, including examining effector-target interactions and host defence responses Essential Knowledge in bioinformatics Essential In depth knowledge of recombinant DNA technology Essential Knowledge of protein structure and biophysics Essential
    Requirement Importance Demonstrated ability to interpret new scientific information and develop novel ideas Essential Experience in using protein structure prediction software Essential Practical experience in generating transient and stable transgenic plant lines Essential Practical experience in biochemistry, including assays to study protein integrity such as western blotting Essential Proficient in molecular cloning techniques Essential Practical experience in studying microbial effectors/virulence proteins Essential Practical experience in techniques to study protein-protein interactions Essential Proven record in scientific writing Essential Experience of supervising, training and mentoring visitors and students Desirable Experience in protein engineering techniques Desirable
    Requirement Importance Attention to detail Essential Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work Essential Ability to maintain confidentiality and security of information where appropriate Essential Willingness to work outside standard working hours when required Essential Promotes equality and values diversity Essential Ability to undertake occasional travel (national and international) related to collaborations and/or seminars Essential Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute Essential

    The John Innes Centre is an independent, international centre of excellence in plant and microbial genetics, carrying out fundamental and strategic research, to train scientists and making our findings available to society.

    Our research makes use of a wide range of disciplines in the biological and chemical sciences including; cell biology, biochemistry, chemistry, genetics and molecular biology.

    We have a diverse and multicultural scientific community and thrive on our European and international links, appointing staff from across the world.

    Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on or nbi.

    We are proud to hold a prestigious Athena SWAN Gold award , recognising the impact of our work in promoting gender equality in science.

    We are also a proud member of the Stonewall Diversity Champion's programme , a founding signatory of the Tecnician Commitment and, as a Disability Confident employer, guarantee to offer an interview to all disabled applicants who meet the essential criteria for the post.

    Crop Genetics

    The Department of Crop Genetics undertakes fundamental research on the biology of cereals, brassicas and legumes to understand the genetic and molecular basis of phenotypic variation.

    This will enable high-yielding, stress and disease resistant varieties, with a particular end-use quality, suitable for an efficient but benign agriculture.

    The successful candidate will be based in the Laboratory of Prof. Saskia Hogenhout, research in the Hogenhout group focuses on dissecting molecular host-microbe-insect interactions.

    Organisms include the insect-vectored phytoplasmas, which are bacterial plant pathogens that are beneficial to their insect vectors, and the sap-feeding plant-colonizing aphids, psyllids, leafhoppers and spittlebugs/froghoppers.

    We use a range of molecular, biochemical, cellular biology and bio-imaging techniques to study processes in live cells and whole organisms along with biophysical techniques to analyze and engineer protein-protein interactions.

    Postdoctoral Researcher

    Salary:
    £35,300 - £43,750 per annum depending on qualifications and experience.
    Contract: 24 months, full time

    Applications are invited for a Postdoctoral researcher to join the group of Prof Saskia Hogenhout (twitter: @The resulting 'Zombie plants' (Nature Microbiology Reviews , New York Times ) are under complete control of the phytoplasmas.

    You must have or be close to finishing a PhD in molecular biology or a similar subject. Knowledge of cell- and microbiology, biochemistry and plant genetics are essential.

    Practical experience inrecombinant DNA technology,protein engineering, plant stable/transient transformation techniques, and studying molecular processes in plant-biotic interactions, such as function-structure analyses of microbial effectors/virulence proteins and their targets, are required.

    You will be part of a basic research environment that involves sharing outcomes via the writing of publications and reports.

    You will give research presentations at group, institute and (inter)national meetings.

    You will be offered opportunities to teach, participate in student supervisory committees and outreach activities, and to engage with industry, entrepreneurs and investors.

    The John Innes Centre is an independent, international centre of excellence in plant and microbial sciences. We nurture a creative, curiosity-led approach to answering fundamental questions in bioscience, and translate that knowledge into societal benefits.

    Our strategic vision, Healthy Plants, Healthy People, Healthy Planet, sets out our ambitious long-term goals for the game changing impact of our science globally.

    Our employees enjoy access to state-of-the-art technology and a diverse range of specialist training opportunities, including support for leadership and management.

    We use a range of molecular, biochemical, cellular biology and bio-imaging techniques to study processes in live cells and whole organisms along with biophysical techniques to analyse and engineer protein-protein interactions.

    This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. Please contact the Human Resources Team if you have any questions regarding your application or visa options.
    We are an equal opportunities employer, actively supporting inclusivity and diversity.

    As a Disability Confident organisation, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.

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