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    Postdoctoral Research Associate in Neuroscience - United Kingdom - British Neuroscience Association

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    Our President Tara Spires-Jones was delighted to be invited to Clarence House to discuss the beneficial effects of cognitively stimulating activities like reading on the brain.

    Research Associate in Neuropathology- Cerebrovascular Disease

    Research Associate in Neuropathology- Cerebrovascular Disease

    We seek an enthusiastic and ambitious postdoctoral research associate based at the Translational and Clinical Research Institute to investigate how specific regulators of microglia state (abundance/function) influence the microglia-endothelial cell axis in the development and progression of white matter abnormalities relevant to vascular cognitive impairment and dementia.

    The project will primarily involve investigation of CNS pathological material from well- characterised clinical study of elderly stroke survivors.

    A range of in vitro, cellular, molecular and quantitative neuroimaging techniques will be used to compare against available clinical, cognitive profile and neuroimaging data to study blood brain barrier integrity, white matter microstructure and inflammation.

    The research associate will be based in the laboratory of Prof. Raj Kalaria As part of the research programme, the lead and key project investigators Prof Karen Horsburgh, Dr.

    Axel Montagne (all University of Edinburgh) will provide advice and expertise to also support a multi-disciplinary approach and an excellent training and mentorship environment as necessary.

    The researcher will be embedded within a rich local neuroscience, immunology, vascular and neuroimaging research community.
    You will have a PhD in a relevant discipline (eg neuroscience, immunology, biomedical sciences).

    Ideally you will have knowledge, interests and skills in cerebrovascular disease and/or dementia and/or neuroimmunology as well as experience in immunohistochemistry or assessing CNS pathological specimens.

    You will work well independently and in a team of other researchers and will drive productive interactions with the key collaborating labs.

    To apply for this position, we will need a copy of your CV and covering letter outlining why you are interested in this project and what skills you have that would benefit the project.

    The role is Fixed Term and tenable for 12 months.

    Please note that if you are successful to this role, you will require medical clearance before you can commence in the role.

    Further information can be obtained by contacting Professor Raj Kalaria, Translational and Clinical Research Institute, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK;

    Office Tel:
    ; As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.
    Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value'


    • Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements
    • Determine appropriate methodologies for research, with advice and support where required
    • Contribute to grant applications submitted by others and in time develop own research objectives and proposals for funding
    • Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids
    • Assess research findings for the need/scope for further investigations
    • Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications
    • Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
    • May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants
    • Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute
    • May contribute to events celebrating the public engagement of science/social sciences/humanities
    • Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment
    • ELISA, Luminex, multi-cytokine arrays to identify biomarkers associated dementia cases
    • To be responsible for managing a database containing the project results against clinical and neuropsychometric data
    • To design studies/experiments and perform the morphological analysis (see details below) of post-mortem brain tissues from elderly post-stroke survivors
    in the area of research


    • Likelihood of advanced skills directly related to the research projects
    • Experience of research with clear transferable skills and some experience or awareness of the research environment
    • Presentations at conferences and/or high-quality publications
    Experience in quantitative morphometric analyses.
    A PhD in a relevant area e.g Neurosciences, Immunology, biomedical sciences
    Honors degree in neuroscience or immunology, pharmacology or biomedical sciences

    We value diversity as well as celebrate, support and thrive on the contributions of all of our employees and the communities they represent.

    We are proud to be an equal opportunities employer and encourage applications from individuals who can complement our existing teams, we believe that success is built on having teams whose backgrounds and experiences reflect the diversity of our university and student population.

    At Newcastle University we hold a silver Athena Swan award in recognition of our good employment practices for the advancement of gender equality.

    We are a Disability Confident employer and will offer an interview to disabled applicants who meet the essential criteria for the role as part of the offer and interview scheme.

    Our application process is conveniently available online and accessible by computer or mobile device 24/7.


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