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    Senior Scientist - United Kingdom - Achilles Therapeutics Limited

    Achilles Therapeutics Limited
    Achilles Therapeutics Limited United Kingdom

    6 days ago

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    Description

    Achilles is a fast paced, trail blazing company. We are breaking new ground with our science creating products that have never been made. As no-one has done what we are doing before, there is no playbook to copy. This means we must innovate, adapt and collaborate across our organisation, working together to solve novel problems. This entrepreneurial spirit and approach runs through our company and those who thrive here are able to cope with anything that is thrown at them, enjoy ambiguity and thrive on making things happen even when there is not a detailed brief.

    We are seeking a motivated, talented and creative Senior Scientist with expertise in immune-oncology, specifically T cell culture and expansion, DC culture, multi-colour Flow Cytometry, and functional immune cell assays. As part of our Immunology Research team in the R&D and Process Development department, you'll be at the forefront of developing the next generation of T cell manufacturing processes.

    The work will be carried out at Achilles Therapeutics in our laboratories at Hammersmith, London.

    Responsibilities

    • Contribute to the administration of multiple lines of research, including experimental design, data record and analysis, and progress reports
    • Contribute to the development of new tools and technologies that will drive improvements of novel cancer therapies
    • Perform T cell functional assays and other immunoassays to characterise neoantigen reactive T cells
    • Participate in Immunology Research team activities and work in close collaboration with other departments in the company
    • Participate in lab rotas and general lab maintenance duties
    • Follow established SOPs and generate suitable SOPs
    • Work flexibly to ensure fresh sample processing
    • Generate rigorous data sets and present reports within the required deadlines
    • Continuously drive for improvement, following the field updates/publications
    • Effectively communicate scientific results to a technical and non-technical audience

    Essential:

    • PhD or equivalent in Immunology/Cell Biology or related field and +5 years of post-doctoral experience
    • Experience in handling and processing human samples and carrying out functional immunoassays
    • Excellent planning, organisational and time management skills, and attention to detail
    • Significant hands-on experience with cell culture techniques, including primary human cell culture of immune cells (e.g. T cells and dendritic cells)
    • Experience with multi-parameter flow cytometry and data analysis
    • Good knowledge of T cell and DC biology, and antigen presentation
    • Excellent planning, organisational and time management skills, attention to detail and critical thinking
    • Ability to work co-operatively as part of a team, as well as independently
    • Self-motivated with strong initiative and drive
    • Ability to work flexibly including evenings and weekends, as required determined by sample processing (Time off in Lieu system in place)

    Desirable:

    • Industry/Biotech experience
    • Experience with molecular biology techniques (e.g., vector design, TCR cloning, lentivirus production)
    • Practical experience on genetic manipulation of cells (e.g., CRISPR)

    This is a permanent role, offering a competitive benefits package

    At Achilles you will enjoy a flexible and dynamic working environment that fosters creativity, leadership, and teamwork. We work hard and deliver a lot

    Our benefits package includes a competitive salary and performance related bonus, group pension plan matched up to 6%, life insurance, private medical insurance, and a tax approved all employee share incentive plan.

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